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Ann Greer Selected Research

BMS 754807

2/2015IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines.
12/2011Dual IGF-1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer.
9/2010Differential mechanisms of acquired resistance to insulin-like growth factor-i receptor antibody therapy or to a small-molecule inhibitor, BMS-754807, in a human rhabdomyosarcoma model.
12/2009BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.

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Ann Greer Research Topics

Disease

4Neoplasms (Cancer)
12/2011 - 01/2009
3Rhabdomyosarcoma
09/2010 - 01/2009
2Sarcoma (Soft Tissue Sarcoma)
09/2010 - 01/2009
2Neuroblastoma
12/2009 - 01/2009
1Colorectal Neoplasms (Colorectal Cancer)
02/2015
1Breast Neoplasms (Breast Cancer)
12/2011
1Resistance To Insulin-Like Growth Factor I
09/2010
1Leukemia
12/2009
1Liposarcoma
12/2009
1Multiple Myeloma
12/2009
1Ewing Sarcoma (Sarcoma, Ewing)
01/2009

Drug/Important Bio-Agent (IBA)

4BMS 754807IBA
02/2015 - 12/2009
2Biomarkers (Surrogate Marker)IBA
02/2015 - 01/2009
2IGF Type 1 Receptor (IGF 1 Receptor)IBA
09/2010 - 01/2009
1Hormones (Hormone)IBA
12/2011
1TamoxifenFDA LinkGeneric
12/2011
1Tyrosine Kinase InhibitorsIBA
12/2011
1Insulin-Like PeptidesIBA
12/2011
1Antineoplastic Agents (Antineoplastics)IBA
12/2011
1Estrogens (Estrogen)FDA Link
12/2011
1Letrozole (Femara)FDA LinkGeneric
12/2011
1Phosphotransferases (Kinase)IBA
09/2010
1AntibodiesIBA
09/2010
1Insulin ReceptorIBA
09/2010
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
09/2010
1Caspase 3 (Caspase-3)IBA
12/2009
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
12/2009
14- chloro- 3',6'- dimethyl- 2,2'- iminodibenzoate (TO 115)IBA
12/2009
1BMS 536924IBA
01/2009

Therapy/Procedure

3Therapeutics
12/2011 - 01/2009